The complement anaphylatoxin receptors are not required for the development of experimental autoimmune uveitis

Academic Article


  • To determine if complement anaphylatoxin-mediated inflammation contributes to the development and progression of experimental autoimmune uveitis (EAU), we induced disease in wild type and complement anaphylatoxin receptor-deficient mice (C3a receptor-/-, C5a receptor-/- and C3aR-/-/C5aR-/-) and evaluated the eyes three weeks post-induction. No differences in disease severity or in disease incidence were seen between wild type controls and anaphylatoxin receptor-deficient mice. Our data indicate that C3a and C5a-mediated functions are not critical to the development of EAU. © 2013 Elsevier B.V.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Read RW; Vogt SD; Barnum SR
  • Start Page

  • 127
  • End Page

  • 129
  • Volume

  • 264
  • Issue

  • 1-2