Background. Prior studies suggest disparities in sepsis risk and outcomes based on place of residence. We sought to examine the association between neighborhood socioeconomic status (nSES) and hospitalization for infection and sepsis. Methods. We conducted a prospective cohort study using data from 30 239 participants in the Reasons for Geographic and Racial Di?erences in Stroke (REGARDS) study. nSES was defned using a score derived from census data and classifed into quartiles. Infection and sepsis hospitalizations were identifed over the period 2003-2012. We ft Cox proportional hazards models, reporting hazard ratios (HRs) with 95% confdence intervals (CIs) and examining mediation by participant characteristics. Results. Over a median follow-up of 6.5 years, there were 3054 hospitalizations for serious infection. Infection incidence was lower for participants in the highest nSES quartile compared with the lowest quartile (11.7 vs 15.6 per 1000 person-years). Afer adjustment for demographics, comorbidities, and functional status, infection hazards were also lower for the highest quartile (HR, 0.84 [95% CI, .73-.97]), with a linear trend (P = .011). However, there was no association between nSES and sepsis at presentation among those hospitalized with infection. Physical weakness, income, and diabetes had modest mediating e?ects on the association of nSES with infection. Conclusions. Our study shows that di?erential infection risk may explain nSES disparities in sepsis incidence, as higher nSES is associated with lower infection hospitalization rates, but there is no association with sepsis among those hospitalized. Mediation analysis showed that nSES may in?uence infection hospitalization risk at least partially through physical weakness, individual income, and comorbid diabetes.