Evidence for network evolution in an Arabidopsis interactome map.

Academic Article


  • Plants have unique features that evolved in response to their environments and ecosystems. A full account of the complex cellular networks that underlie plant-specific functions is still missing. We describe a proteome-wide binary protein-protein interaction map for the interactome network of the plant Arabidopsis thaliana containing about 6200 highly reliable interactions between about 2700 proteins. A global organization of plant biological processes emerges from community analyses of the resulting network, together with large numbers of novel hypothetical functional links between proteins and pathways. We observe a dynamic rewiring of interactions following gene duplication events, providing evidence for a model of evolution acting upon interactome networks. This and future plant interactome maps should facilitate systems approaches to better understand plant biology and improve crops.
  • Authors

    Published In

  • Science  Journal
  • Keywords

  • 14-3-3 Proteins, Arabidopsis, Arabidopsis Proteins, Evolution, Molecular, Genes, Plant, Plant Growth Regulators, Protein Interaction Mapping, Proteome, Signal Transduction, Transcription Factors, Ubiquitination
  • Digital Object Identifier (doi)

    Author List

  • Arabidopsis Interactome Mapping Consortium
  • Start Page

  • 601
  • End Page

  • 607
  • Volume

  • 333
  • Issue

  • 6042