A tri-O-bridged Diels-Alder adduct from cortex mori radicis

Academic Article


  • Sanggenon X, an unusual tri-O-bridged Diels-Alder adduct, was isolated from Cortex Mori Radicis. Its structure was established by spectroscopic analysis, including NMR and HR-MS (High Resolution Mass Spectrometry). Sanggenon X contained three O-bridged rings, where the oxygenated bridgeheads were all quaternary carbons. Chemical methylation was carried out to deduce the linkages of the three O-bridges. The absolute configuration was determined by calculating the ECD (Electronic Circular Dichroism) using the TDDFT (Time-Dependent Density Functional Theory) method. Sanggenon X showed significant antioxidant activity against Fe2+-Cys-induced lipid peroxidation in rat liver microsomes, and was as effective as the positive control, curcumin.
  • Authors

    Published In

  • Molecules  Journal
  • Digital Object Identifier (doi)

    Author List

  • Lu AQ; Chen MH; Gao J; Wang L; Yang HY; Li L; Zhang B; He HK; Wang SJ
  • Volume

  • 23
  • Issue

  • 1