Conformationally constrained precursors to retinoic acid analogs which stabilize the 9Z-configuration

Academic Article


  • The iodine-catalyzed isomerization (dark) of (2Z,4E)-4-(2′-isopropylidenecyclohexylidene)-3-methyl-2,4-butadien al and (2Z,4E)-4-(2′-isopropyl-3′-methyl-2′-cyclohexen- 1′-ylidene)-3-methyl-2-butenal, precursors to conformationally defined 6-s-cis and 6-s-trans retinoic acid analogs, resulted in the formation of isomer mixtures for which the 9Z-configuration [using retinoic acid numbering] is most stable. © 1995.
  • Digital Object Identifier (doi)

    Author List

  • Robinson CY; Waterhous DV; Muccio DD; Brouillette WJ
  • Start Page

  • 953
  • End Page

  • 958
  • Volume

  • 5
  • Issue

  • 9