Palmadorin chemodiversity from the Antarctic nudibranch Austrodoris kerguelenensis and inhibition of Jak2/STAT5-dependent HEL leukemia cells

Academic Article


  • Detailed investigation of the Antarctic nudibranch Austrodoris kerguelenensis has resulted in the isolation of a diverse suite of new diterpenoid glyceride esters (1-16) related to the palmadorins (17-19), including one (palmadorin L (9)) that is the first halogenated diterpene from this well-studied nudibranch. Previous collections of A. kerguelenensis from McMurdo Sound, the Weddell Sea and the Western Antarctic Peninsula have afforded related diterpene glycerides, a natural product class implicated as a chemical defense in nudibranchs. In this paper we describe the isolation, structure elucidation, and stereochemical analysis of sixteen new palmadorins using a combination of one- and two-dimensional NMR techniques. Palmadorin A (17), B (18), D (1), M (10), N (11), and O (12) inhibit human erythroleukemia (HEL) cells with low micromolar IC 50's, and palmadorin M inhibits Jak2, STAT5, and Erk1/2 activation in HEL cells and causes apoptosis, at 5 μM. © 2012 Elsevier Ltd. All rights reserved.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 11747412
  • Author List

  • Maschek JA; Mevers E; Diyabalanage T; Chen L; Ren Y; McClintock JB; Amsler CD; Wu J; Baker BJ
  • Start Page

  • 9095
  • End Page

  • 9104
  • Volume

  • 68
  • Issue

  • 44