Early effects of experimental diabetes on central catecholamine concentrations

Academic Article


  • Six days after induction of diabetes norepinephrine (NE), 3,4-dihydroxyphenylalanine and dopamine concentrations were determined in spinal cord, cerebellum, pons/medulla oblongata and the remaining brain of diabetic rats. Only cerebellar NE levels were significantly increased by 21% compared to age-matched controls. This effect was not seen when diabetic rats received insulin replacement therapy. Fifty-two days after induction of diabetes cerebellar NE levels in diabetic rats were further increased (+37%), implying an enduring and progressive effect. The data show that even with a short period of uncontrolled diabetes central neurochemical alterations occur. © 1988.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Wesselmann U; Konkol RJ; Roerig DL; Harder DR
  • Start Page

  • 651
  • End Page

  • 654
  • Volume

  • 20
  • Issue

  • 5