Female Sexual Function: The Role of Animal Models in Assessing Female Sexual Dysfunction

Chapter

Abstract

  • Basic science research in animal models is important for understanding pathophysiological mechanisms underlying female sexual dysfunction and chronic pelvic pain syndromes in females. In vivo animal models, primarily rodents, of female sexual behavior (desire, motivation, arousal, and orgasm) and pelvic pain have been developed. These models employ either simple paradigms, such as monitoring proceptive behavior or responses to pelvic organ distension, or more complex learning paradigms. Valuable information on the neural pathways and neurotransmitters regulating the central and peripheral control of sexual function and changes that occur with dysfunction have been gained from animal models that have shown translational relevance in women. New research understanding genital sensory inputs and their regulation in females and the etiology of women's sexual dysfunction disorders have led to the development of more translatable preclinical models, which are important for future development of treatment options for sexual dysfunctions in women presenting with or without pain.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9780128035061
  • Start Page

  • 45
  • End Page

  • 60