Extending recent research efforts on the effects of personality and moods at work, this study examined the impact of personality traits and mood states in job burnout. Specifically, the field study examined the role of 2 personality traits and positive and negative moods (states) in burnout among nurses working at 2 hospitals. Results indicate that extra-version significantly predicted the diminished accomplishment component of burnout, and neuroticism significantly predicted the exhaustion and depersonalization components. Thus, the findings indicate that personality dimensions predict burnout components differentially. Further, positive moods mediated the relationship between extraversion and accomplishment, while negative moods partially mediated between neuroticism and exhaustion. Thus, moods exhibited both direct and mediating effects. Implications for management and suggestions for future research are offered.