Hepatoprotective effects of Panax notoginseng: Ginsenosides -Re and -Rg(1) as its active constituents in D-galactosamine/lipopolysaccharide-induced liver injury.

Academic Article

Abstract

  • The hepatoprotective effects of the methanol and water extracts of the roots of Panax notoginseng were studied on various animal models. The methanol and water extracts of P. notoginseng showed a significant activity in carbon tetrachloride-induced liver injury in rats. However, the methanol extract was found to be more active. The hepatoprotective effects of the methanol extract was further evaluated using D-galactosamine as well as heat-killed Propionibacterium acnes/lipopolysaccharide-induced liver injury models. Two major isolates from the methanol extract, ginsenosides-Re and -Rgl, showed a significant hepatoprotective effect on D-galactos-amine/lipopolysaccharide-induced liver injury in mice.
  • Published In

  • Phytomedicine  Journal
  • Digital Object Identifier (doi)

    Author List

  • Prasain JK; Kadota S; Basnet P; Hase K; Namba T
  • Start Page

  • 297
  • End Page

  • 303
  • Volume

  • 2
  • Issue

  • 4