Metabolic Origins of Heart Failure

Academic Article


  • For more than half a century, metabolic perturbations have been explored in the failing myocardium, highlighting a reversion to a more fetal-like metabolic profile (characterized by depressed fatty acid oxidation and concomitant increased reliance on use of glucose). More recently, alterations in ketone body and amino acid/protein metabolism have been described during heart failure, as well as mitochondrial dysfunction and perturbed metabolic signaling (e.g., acetylation, O-GlcNAcylation). Although numerous mechanisms are likely involved, the current review provides recent advances regarding the metabolic origins of heart failure, and their potential contribution toward contractile dysfunction of the heart.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Wende AR; Brahma MK; McGinnis GR; Young ME
  • Start Page

  • 297
  • End Page

  • 310
  • Volume

  • 2
  • Issue

  • 3