Survival outcomes for stage-matched endoscopic and open resection of olfactory neuroblastoma

Academic Article


  • Background: Advanced-stage olfactory neuroblastoma requires multimodal therapy for optimal outcomes. Debate exists over endoscopic endonasal surgery in this situation. Stage-matched open and endoscopic surgical therapy were compared. Methods: Patients from 6 cancer institutions were assessed. Stratification included dural involvement, Kadish stage, nodal disease, Hyams' grade, approach, and margin status. At follow-up, local control, nodal status, and evidence of distant metastases were recorded with any subsequent therapy. Statistical analyses to identify risk factors for developing recurrence and survival differences were performed. Results: One hundred nine patients were assessed (age 49.2 ± 13.0 years; 46% women) representing Kadish A stage (10%), Kadish B stage (25%), and Kadish C stage (65%). The majority of the patients (61.5%) underwent endoscopic resection, 53.5% within Kadish C stage. Within-stage survival analysis favored endoscopic subgroup for Kadish C stage (log-rank P =.017) nonsignificant for Kadish B stage (log-rank P =.39). Conclusion: Stage-matched survival was better for the endoscopically treated group compared to the open surgery group, with high negative margin resections obtained.
  • Digital Object Identifier (doi)

    Author List

  • Harvey RJ; Nalavenkata S; Sacks R; Adappa ND; Palmer JN; Purkey MT; Schlosser RJ; Snyderman C; Wang EW; Woodworth BA
  • Start Page

  • 2425
  • End Page

  • 2432
  • Volume

  • 39
  • Issue

  • 12