Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa

Academic Article


  • A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of spectroscopic and crystallographic analysis, the central seven-membered ring is hypothesized to originate from a ring-expansion of a spongian precursor. Darwinolide displays 4-fold selectivity against the biofilm phase of methicillin-resistant Staphylococcus aureus compared to the planktonic phase and may provide a scaffold for the development of therapeutics for this difficult to treat infection.
  • Published In

  • Organic Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Von Salm JL; Witowski CG; Fleeman RM; McClintock JB; Amsler CD; Shaw LN; Baker BJ
  • Start Page

  • 2596
  • End Page

  • 2599
  • Volume

  • 18
  • Issue

  • 11