Suppression of sucrose intake by continuous near-celiac and intravenous cholecystokinin infusions in rats.

Academic Article

Abstract

  • We compared suppression of intake of 30% sucrose produced by continuous aortal (near celiac) and intravenous infusions of cholecystokinin octapeptide (CCK-8). Adult, male Sprague-Dawley rats received 21-min infusions of saline or 100-1,600 ng CCK-8. Sucrose was available for 20 min, beginning 1 min after onset of infusions. Significant reductions in intake were produced by near-celiac infusions of 400, 800, and 1,600 ng CCK-8, but only the two highest doses affected intake when infused intravenously. In a second experiment, which replicated previous observations, near-celiac bolus infusions of 70 ng CCK-8 significantly reduced sucrose intake but intravenous infusions did not. Behavioral observations indicated that although bolus infusions produced immediate disruption of feeding, suggesting an aversive effect, effects of continuous CCK-8 infusions on temporal intake patterns were consistent with enhancement of satiety. These data provide further evidence that CCK-8 acts on a site within the upper gastrointestinal tract to produce satiety.
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    Published In

    Keywords

  • Analysis of Variance, Animals, Celiac Artery, Dietary Carbohydrates, Dose-Response Relationship, Drug, Infusions, Intra-Arterial, Infusions, Intravenous, Male, Rats, Rats, Sprague-Dawley, Satiation, Sincalide, Sucrose
  • Digital Object Identifier (doi)

    Author List

  • Cox JE; Perdue GS; Tyler WJ
  • Start Page

  • R150
  • End Page

  • R155
  • Volume

  • 268
  • Issue

  • 1 Pt 2