Inhibition by acetyl-CoA of hepatic carnitine acyltransferase and fatty acid oxidation

Academic Article

Abstract

  • At micromolar concentrations, acetyl-CoA inhibited hepatic carnitine acyltransferase activity and mitochondrial fatty acid oxidation. The inhibitory effects were not nearly as potent on a molar basis as those of malonyl-CoA; nevertheless, the cytosolic concentrations of acetyl-CoA, as yet unknown, may be sufficient (>30 μM) to curtail appreciably the mitochondrial transfer of long-chain acyl-CoA units and fatty acid oxidation. Hence acetyl-CoA may also partially regulate hepatic ketogenesis.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • McCormick K; Notar Francesco VJ; Sriwatanakul K
  • Start Page

  • 499
  • End Page

  • 502
  • Volume

  • 216
  • Issue

  • 2