Porphyrin-linked oligonucleotides. Synthesis and sequence-specific modification of ssDNA

Academic Article


  • Oligonucleotide derivatives bearing hemin and deuterohemin groups were synthesized. The derivatives efficiently react with the complementary nucleotide sequence in ssDNA forming covalent adducts and piperidine-labile sites. In the case of the deuterohemin derivative, some direct cleavage of the target DNA occurs. © 1990.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Frolova EI; Ivanova EM; Zarytova VF; Abramova TV; Vlassov VV
  • Start Page

  • 101
  • End Page

  • 104
  • Volume

  • 269
  • Issue

  • 1