The Phosphotransferase System of Streptomyces coelicolor Is Biased for N-Acetylglucosamine Metabolism

Academic Article


  • Mutation of the crr-ptsI gene locus revealed that Streptomyces coelicolor uses the phosphotransferase system (PTS) for N-acetylglucosamine uptake. crr, ptsI, and ptsH, which encode the three general PTS phosphotransferases, are induced by N-acetylglucosamine but not by other PTS substrates. Thus, the S. coelicolor PTS is biased for N-acetylglucosamine utilization, a novel feature that distinguishes this PTS from others.
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    Digital Object Identifier (doi)

    Author List

  • Nothaft H; Dresel D; Willimek A; Mahr K; Niederweis M; Titgemeyer F
  • Start Page

  • 7019
  • End Page

  • 7023
  • Volume

  • 185
  • Issue

  • 23