Constraint-Induced Movement therapy can improve hemiparetic progressive multiple sclerosis. Preliminary findings

Academic Article


  • Objective: To evaluate whether Constraint-Induced Movement therapy (CI therapy) may benefit chronic upper extremity hemiparesis in progressive multiple sclerosis (MS). Methods: Five patients with progressive MS, who had chronic upper extremity hemiparesis and evidence for learned non-use of the paretic limb in the life situation, underwent 30 hours of repetitive task training and shaping for the paretic limb over 2-10 consecutive weeks, along with physical restraint of the less-affected arm and a "transfer package" of behavioral techniques to reinforce treatment adherence. Results: The patients showed significantly improved spontaneous, real-world limb use at post-treatment and 4 weeks post-treatment, along with improved fatigue ratings and maximal movement ability displayed in a laboratory motor test. Conclusions: The findings suggest for the first time that slowly progressive MS may benefit from CI therapy. Further studies are needed to determine the retention of treatment responses. © SAGE Publications 2008.
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    Author List

  • Mark VW; Taub E; Bashir K; Uswatte G; Delgado A; Bowman MH; Bryson CC; McKay S; Cutter GR
  • Start Page

  • 992
  • End Page

  • 994
  • Volume

  • 14
  • Issue

  • 7