Nanoscale optomechanical actuators for controlling mechanotransduction in living cells

Academic Article


  • To control receptor tension optically at the cell surface, we developed an approach involving optomechanical actuator nanoparticles that are controlled with near-infrared light. Illumination leads to particle collapse, delivering piconewton forces to specific cell surface receptors with high spatial and temporal resolution. We demonstrate optomechanical actuation by controlling integrin-based focal adhesion formation, cell protrusion and migration, and T cell receptor activation.
  • Published In

  • Nature methods  Journal
  • Digital Object Identifier (doi)

    Author List

  • Liu Z; Liu Y; Chang Y; Seyf HR; Henry A; Mattheyses AL; Yehl K; Zhang Y; Huang Z; Salaita K
  • Start Page

  • 143
  • End Page

  • 146
  • Volume

  • 13
  • Issue

  • 2