Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

Academic Article


  • In mice deficient in either lymphotoxin-α (LT-α) or the type I tumor necrosis factor (TNF) receptor, but not the type II TNF receptor, germinal centers failed to develop in peripheral lymphoid organs. Germinal center formation was restored in LT-α-deficient mice by transplantation of normal bone marrow, indicating that the LT-α-expressing cells required to establish this lymphoid structure are derived from bone marrow.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Matsumoto M; Mariathasan S; Nahm MH; Baranyay F; Peschon JJ; Chaplin DD
  • Start Page

  • 1289
  • End Page

  • 1291
  • Volume

  • 271
  • Issue

  • 5253