Predicting mid-term all-cause mortality in patients undergoing elective endovascular repair of a descending thoracic aortic aneurysm

Academic Article


  • Introduction: All-cause mortality in patients after repair of aortic aneurysms of the descending thoracic aorta thoracic endovascular aortic repair (TEVAR) is relatively high at mid-term follow-up. The aim of this study was to derive and validate a system that could predict all-cause mortality after TEVAR to aid with patient selection. Methods: The MOTHER database contained 625 patients that underwent elective surgery for descending thoracic aortic aneurysms. Univariate analysis identified preoperative factors associated with mid-term all-cause mortality, and a Cox proportional hazards model was developed. The model was internally validated using Kaplan-Meier comparison of observed vs predicted mortality. External validation was performed using a data set from the University of Florida College of Medicine. Results: There were 625 patients that underwent TEVAR for descending thoracic aortic aneurysm in the MOTHER database and 231 in the University of Florida College of Medicine validation set. The mid-term mortality rate at 6 years of follow-up was 34.4% and 34%, respectively. The all-cause mortality risk score was calculated using 0.0398 × (age)0.516 × (renal insufficiency)0.46 × (previous cerebrovascular disease) 0.352 × (prior tobacco use)0.376 × (number of devices >2)0.016 × (maximum aneurysm diameter). Using this score, low-, medium-, and high-risk groups were defined, with predicted survival at 5 years of 80%, 60%, and 40%. Patients at high risk of mid-term all-cause death were identified in the validation cohort using the prediction rule. Conclusions: Identifying patients with a limited life expectancy after TEVAR is possible using a preoperative risk-stratification system. This information can be used to inform decision making regarding when and whether to proceed with TEVAR.
  • Authors

    Published In

  • Annals of Surgery  Journal
  • Digital Object Identifier (doi)

    Pubmed Id

  • 18425933
  • Author List

  • Patterson BO; Vidal-Diez A; Holt PJ; Scali ST; Beck AW; Thompson MM
  • Start Page

  • 1162
  • End Page

  • 1167
  • Volume

  • 264
  • Issue

  • 6