Effects of chronic hyperinsulinaemia on hepatic enzymes involved in lipogenesis and carbohydrate metabolism in the young rat

Academic Article


  • Chronic (6 days) hyperinsulinaemia in young rats produced lower blood glucose concentrations and augmented body- and liver-weight gain. The insulin-treated rats had increased hepatic activities of citrate-cleavage enzyme, 'malic' enzyme and high-substrate (6.6mM-phosphoenolpyruvate) pyruvate kinase, and decreased glucose 6-phosphatase. There were no changes in activities of phosphoenolpyruvate carboxykinase, phosphofructokinase, low-substrate (1.3mM-phosphoenolpyruvate) pyruvate kinase, glucokinase and hexokinase.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • McCormick KL; Widness JA; Susa JB; Schwartz R
  • Start Page

  • 327
  • End Page

  • 331
  • Volume

  • 172
  • Issue

  • 2