Upgrading prostate cancer following proton beam therapy

Academic Article


  • Pre-and post-radiation therapy (RT) effects on prostate histology have not been rigorously studied, but there appears to be a correlation between escalating radiation dosage and increasing post-RT histologic changes. Despite this dose-response relationship, radiation-induced changes may be heterogenous among different patients and even within a single tumor. When assessing residual tumor it is important to understand biopsy evaluation in the post-RT setting. We present the case of a poorly differentiated prostate adenocarcinoma following proton beam RT in a 45-year-old man with pre-RT Gleason 4 + 3 = 7 disease diagnosed in the setting of an elevated serum prostate-specific antigen level.
  • Published In

  • Urology Annals  Journal
  • Digital Object Identifier (doi)

    Author List

  • Logan JK; Rais-Bahrami S; Merino MJ; Pinto PA
  • Start Page

  • 262
  • End Page

  • 264
  • Volume

  • 7
  • Issue

  • 2