Semi-automated preparation of the dopamine transporter ligand [(18)F]FECNT for human PET imaging studies.

Academic Article


  • The fluorine-18 labeled dopamine transport (DAT) ligand 2 beta-carbomethoxy-3beta-(4-chlorophenyl)-8-(2-fluoroethyl)nortropane (FECNT) has shown promising properties as an in vivo DAT imaging agent in human and monkey PET studies. A semi-automated synthesis has been developed to reliably produce [(18)F]FECNT in a 16% decay corrected yield. This method utilizes a new [(18)F]fluoralkylating agent and provides high purity [(18)F]FECNT in a formulation suitable for human use.
  • Published In


  • Dopamine Plasma Membrane Transport Proteins, Fluorine Radioisotopes, Humans, Ligands, Membrane Glycoproteins, Membrane Transport Proteins, Nerve Tissue Proteins, Nortropanes, Positron-Emission Tomography, Radiopharmaceuticals
  • Digital Object Identifier (doi)

    Pubmed Id

  • 22549720
  • Author List

  • Voll RJ; McConathy J; Waldrep MS; Crowe RJ; Goodman MM
  • Start Page

  • 353
  • End Page

  • 361
  • Volume

  • 63
  • Issue

  • 3