Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET.

Academic Article

Abstract

  • The nortropane cocaine analogue, 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane (ZIENT), is a high affinity, selective serotonin transporter (SERT) ligand that has shown promise as a SERT imaging agent for single photon computed tomography (SPECT) when labeled with I-123. Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging.

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    Published In

    Keywords

  • Animals, Brain, Carbon Radioisotopes, Isotope Labeling, Macaca fascicularis, Macaca mulatta, Male, Nortropanes, Positron-Emission Tomography, Radiopharmaceuticals, Serotonin Plasma Membrane Transport Proteins

    • Digital Object Identifier (doi)

    Author List

  • Plisson C; Jarkas N; McConathy J; Voll RJ; Votaw J; Williams L; Howell LL; Kilts CD; Goodman MM

    • Start Page

  • 942

    • End Page

  • 946

    • Volume

  • 49

    • Issue

  • 3