55Cobalt complexes with pendant carbohydrates as potential PET imaging agents

Academic Article


  • Bis-ligand cobalt(II) complexes of four 3-hydroxy-4-pyridinone ligands with pendant carbohydrates were synthesized and examined for their potential as radiopharmaceuticals. Non-radioactive complexes were prepared on the macroscopic scale and characterized by elemental analysis, mass spectrometry, IR and UV/visible spectroscopy. Facile radiolabeling produced the 55Co complexes in high radiochemical yields (>95%). Identification of the radiolabeled compounds was accomplished by HPLC comparison with the corresponding non-radioactive complexes. © 2007 Elsevier Ltd. All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Ferreira CL; Lapi S; Steele J; Green DE; Ruth TJ; Adam MJ; Orvig C
  • Start Page

  • 1303
  • End Page

  • 1308
  • Volume

  • 65
  • Issue

  • 12