Differential binding of the HIV-1 envelope to phosphatidylserine receptors

Academic Article


  • Prior work has shown that the HIV-1 envelope of the human immunodeficiency virus (HIV) interacts directly with T-cell immunoglobulin mucin (TIM) family proteins. Herein, we demonstrate that HIV-1 envelope glycoproteins from varying HIV-1 clades bind differentially to TIM proteins and functionally similar proteins acting as phosphatidylserine (PtdSer) receptors. Using enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance (SPR) technology, we show that lysate containing HIV-1 envelope and recombinant HIV-1 envelope glycoproteins bind TIM-4 and advanced glycosylation end product-specific receptor (AGER). The complex binding of HIV-1 UG21 gp140 to TIM-4 or AGER suggests a biphasic interaction with these proteins.
  • Digital Object Identifier (doi)

    Author List

  • Gu L; Sims B; Krendelchtchikov A; Tabengwa E; Matthews QL
  • Start Page

  • 1962
  • End Page

  • 1966
  • Volume

  • 1859
  • Issue

  • 10