Serum α-fetoprotein levels in Beckwith-Wiedemann syndrome

Academic Article


  • We conducted a retrospective study that compared serial α-fetoprotein (AFP) concentrations obtained from 22 children with Beckwith-Wiedemann syndrome (BWS) with levels established for healthy children. The AFP concentration is greater in patients with BWS and declines during the postnatal period at a significantly slower rate than what is reported in healthy children. AFP levels obtained in the course of routine tumor screening in children with BWS should be interpreted with a normal curve established specifically for BWS rather than with previously published data for healthy infants and children.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Everman DB; Shuman C; Dzolganovski B; O’Riordan MA; Weksberg R; Robin NH
  • Start Page

  • 123
  • End Page

  • 127
  • Volume

  • 137
  • Issue

  • 1