Quantification of NF1 transcripts reveals novel highly expressed splice variants

Academic Article


  • Previously, we have shown that the NF1 gene gives rise to multiple novel splice variants. In the present study, nine NF1 variants were quantified by real-time PCR in various human tissues. Some of these variants were expressed at low to moderate low levels and possible implications of these findings are discussed. Interestingly, two variants (NF1-ΔE4b and NF1-ΔE43) were shown to be highly expressed in specific tissues. NF1-ΔE43 lacks a nuclear targeting sequence and might be functionally different from full-length NF1. These novel NF1 splice variants might expand our understanding of the role of neurofibromin. © 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
  • Published In

  • FEBS Letters  Journal
  • Digital Object Identifier (doi)

    Author List

  • Vandenbroucke I; Vandesompele J; De Paepe A; Messiaen L
  • Start Page

  • 71
  • End Page

  • 76
  • Volume

  • 522
  • Issue

  • 1-3