Extragonadal germ-cell tumors: a ten-year experience.

Academic Article


  • Extragonadal germ-cell tumors (EGCT) are uncommon and biologically distinct from their gonadal counterparts. Thirty-seven patients who had EGCT were treated over a ten-year period at the Regional Cancer Centre, Trivandrum, India. There were 26 men and boys and 11 women and girls. The sites of primary tumor were mediastinum (n=18), central nervous system (n=5), sacrococcygeal region (n=4), retroperitoneum (n=2), and other sites (n=8). After combined modality therapy, 13 of 18 patients who had mediastinal EGCT--1 of 2 with retroperitoneal, 1 of 4 with sacrococcygeal, 0 of 5 with central nervous system, and 2 of 8 patients with tumor in other sites-were alive with no evidence of disease at a median follow-up of 16 months. The overall 5-year survival rate was 40%. Histologic subtype and elevated marker levels were the significant prognostic factors on univariate analysis.
  • Keywords

  • Adolescent, Adult, Central Nervous System Neoplasms, Combined Modality Therapy, Female, Germinoma, Humans, Male, Mediastinal Neoplasms, Prognosis, Retroperitoneal Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Jacob R; Ramadas K; Jyothirmayi R; Kusumakumary P; Nair MK
  • Start Page

  • 198
  • End Page

  • 202
  • Volume

  • 21
  • Issue

  • 2