Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition

Academic Article

Abstract

  • The identification of individuals genetically susceptible to cancer calls for preventive measures to minimize the cancer risk in these high-risk populations. Immune prevention is made necessary by the anticipated health threat, but lack of enough high-affinity T cells against tumor-associated antigens and the unpredictability of tumor antigens make antigen-based immune prevention untenable for cancer. To address this issue, we explored a non-antigen-based cancer immune prevention strategy using the transgenic adenocarcinoma of mouse prostate model that spontaneously develops prostate cancer with 100% penetrance. We show that targeted mutation of the lymphotoxin α ( LT α) gene efficiently rescued tumor-reactive T cells, drastically reduced cancer incidence, and almost completely ablated metastasis. Remarkably, short-term treatments with the fusion protein consisting of constant region of IgG and extracellular domain of lymphotoxin β receptor (LTβRIg) interrupted clonal deletion, reduced the size of the primary cancer, and completely prevented metastasis later in life. Our data demonstrated the value of non-antigen-based immune prevention for those with a genetic predisposition to cancer.
  • Digital Object Identifier (doi)

    Author List

  • Zhou P; Fang X; McNally BA; Yu P; Zhu M; Fu Y-X; Wang L; Liu Y; Zheng P
  • Start Page

  • 17134
  • End Page

  • 17139
  • Volume

  • 106
  • Issue

  • 40