Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene

Academic Article

Abstract

  • Background Chronic obstructive pulmonary disease (COPD) is characterized by marked phenotypic heterogeneity. Most previous studies have focused on COPD subjects with FEV1 < 80% predicted. We investigated the clinical and genetic heterogeneity in subjects with mild airflow limitation in spirometry grade 1 defined by the Global Initiative for chronic Obstructive Lung Disease (GOLD 1).
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Lee JH; Cho MH; McDonald MLN; Hersh CP; Castaldi PJ; Crapo JD; Wan ES; Dy JG; Chang Y; Regan EA
  • Start Page

  • 1469
  • End Page

  • 1480
  • Volume

  • 108
  • Issue

  • 10