Isolated diastolic hypertension and incident heart failure in community-dwelling older adults: Insights from the Cardiovascular Health Study

Academic Article


  • Background Isolated systolic hypertension and isolated diastolic hypotension are common in older adults and associated with a higher risk of incident heart failure (HF). However, little is known about the prevalence and impact of isolated diastolic hypertension in this population. Methods In the Cardiovascular Health Study (CHS), of the 5776 community-dwelling older adults ≥ 65 years who had data on baseline systolic and diastolic blood pressure (SBP and DBP), 28 had isolated diastolic hypertension (DBP ≥ 90 mm Hg and SBP < 140 mm Hg). From the 5748 without isolated diastolic hypertension, we excluded those with SBP ≥ 120 mm Hg (n = 4451), DBP 80–89 mm Hg (n = 20), DBP < 60 mm Hg (n = 425), normal BP taking anti-hypertensive medications (n = 311), normal BP taking no anti-hypertensive medications but with history of hypertension (n = 38), and baseline HF (n = 5). The final cohort of 524 participants included 27 with isolated diastolic hypertension. Results Patients (n = 524) had a mean (± SD) age of 71 (± 5) years, 58% were women and 9% African American. There were no significant between-group age or sex differences; 37% of those with isolated diastolic hypertension (versus 7% without) were African American. Incident HF occurred in 19% and 7% of participants with and without isolated diastolic hypertension, respectively (multivariable-adjusted hazard ratio {HR}, 4.65; 95% confidence interval {CI}, 1.09–19.90; p = 0.038). There was a trend toward higher cardiovascular mortality (HR, 4.59; 95% CI, 0.92–23.88; p = 0.063). Conclusion Among community-dwelling older adults, isolated diastolic hypertension is rare and is associated with higher risk for incident HF and cardiovascular mortality.
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    Author List

  • Sheriff HM; Tsimploulis A; Valentova M; Anker MS; Deedwania P; Banach M; Morgan CJ; Blackman MR; Fonarow GC; White M
  • Start Page

  • 140
  • End Page

  • 143
  • Volume

  • 238