Impact of surgical therapies on sleep and alertness in Parkinson’s disease



  • Surgical therapies for Parkinson’s disease (PD) play an increasingly important role in the treatment of motor symptoms that are refractory to medical management. These therapies include deep brain stimulation, lesional/ablation surgery of brain structures, and placement of an intrajejunal tube to administer continuous drug delivery of levodopa/carbidopa intestinal gel (LCIG). Sleep dysfunction and excessive daytime sleepiness are very common among patients with Parkinson’s disease and negatively impact quality of life. For this reason, understanding the impact of surgical therapies on these symptoms can provide additional insights into strategies for optimizing outcomes and provide a better understanding of the pathophysiology of sleep disorders in PD patients. In this chapter, we review the available data on the effects of surgical therapies on sleep architecture, sleep quality, and daytime vigilance and discuss the need for further study to fully understand the mechanisms underlying changes in sleep following surgical intervention.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9783709116302
  • Start Page

  • 195
  • End Page

  • 207