Mucosal escherichia coli bactericidal activity and immune mediators are associated with HIV-1 seroconversion in women participating in the HPTN 035 trial

Academic Article


  • The mucosal environment may impact the risk for human immunodeficiency virus type 1 (HIV-1) acquisition. Immune mediators were measured in vaginal fluid collected from HPTN 035 participants who acquired HIV-1 and from those who remained HIV-1 negative (controls). Mediator concentrations were similar in samples obtained before as compared to after HIV-1 acquisition in the 8 seroconverters. Compared with controls, seroconverters were more likely to have detectable levels of HD-2 (odds ratio [OR], 2.39; P =. 005) and greater Escherichia coli bactericidal activity (OR, 1.22; P =. 01) prior to seroconversion. E. coli bactericidal activity remained significant in a multivariable analysis (P =. 02) and may be a biomarker for HIV-1 acquisition. © 2012 The Author.
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    Digital Object Identifier (doi)

    Author List

  • Dezzutti CS; Richardson BA; Marrazzo JM; Tugetman J; Ramjee G; Taha T; Chirenje ZM; Abdool Karim SS; Hillier SL; Herold BC
  • Start Page

  • 1931
  • End Page

  • 1935
  • Volume

  • 206
  • Issue

  • 12