Patients older than 65 years take an average of seven medications daily; more than 10% of geriatric admissions to general medical services are for medication reactions. Practical ways to reduce the danger of drug-induced disease and adverse drug reactions include frequent medication review and simplification of the medical regimen. Give both oral and written instructions, and check periodically to make sure instructions are being followed. Automatic prescription refilling and use of multiple physicians or pharmacies set the stage for polypharmacy. Three investments in time and effort can greatly improve clinical outcomes and patient satisfaction: learning the adverse effects and interactions, treating the whole patient (not a disease), and explaining to patients that drugs are not the only way to manage disease.