Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestris: Indications of cytoprotective activity in murine hepatocyte culture

Academic Article

Abstract

  • Tribulusamides A (1) and B (2), new lignanamides embracing two cinnamic amide parts joined in a cis configuration, were isolated from the fruits of Tribulus terrestris, together with four known compounds, N-trans- feruloyltyramine (3), terrestriamide (4), N-trans-coumaroyltyramine (5), and β-sitosterol. The structures were elucidated by 2D-NMR spectroscopy. Addition of compounds 1-5, especially 1 and 2, to primary cultured mouse hepatocytes significantly prevented cell death induced by D-galactosamine (D- GaIN)/tumor necrosis factor a (TNF-α).
  • Digital Object Identifier (doi)

    Pubmed Id

  • 18645351
  • Author List

  • Li JX; Shi Q; Xiong QB; Prasain JK; Tezuka Y; Hareyama T; Wang ZT; Tanaka K; Namba T; Kadota S
  • Start Page

  • 628
  • End Page

  • 631
  • Volume

  • 64
  • Issue

  • 7