Hydroxymethyl analogs of 5-benzylacyclouriding (BAU) and 5-benzyloxybenzylacyclouridine (BBAU) were synthesized by the condensation of appropriately blocked 2- (chloromethyl)glycerols with substituted 2,4-dimethoxypyrimidines. The HM derivatives were found to be potent inhibitors of the enzyme uridine phosphorylase and to potentiate significantly the growth-inhibiting action of FdUrd in cell culture. © 1984, Taylor & Francis Group, LLC. All rights reserved.
