Synthesis and Biological Activity of Hydroxymethyl Analogs of 5-Benzylacyclouridine and 5-Benzylckybenzyiacyclogridine

Academic Article

Abstract

  • Hydroxymethyl analogs of 5-benzylacyclouriding (BAU) and 5-benzyloxybenzylacyclouridine (BBAU) were synthesized by the condensation of appropriately blocked 2- (chloromethyl)glycerols with substituted 2,4-dimethoxypyrimidines. The HM derivatives were found to be potent inhibitors of the enzyme uridine phosphorylase and to potentiate significantly the growth-inhibiting action of FdUrd in cell culture. © 1984, Taylor & Francis Group, LLC. All rights reserved.
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    Author List

  • Chu SH; Chen ZH; Rowe EC; Naguib FNM; el Kouni MH; Chu MY
  • Start Page

  • 303
  • End Page

  • 311
  • Volume

  • 3
  • Issue

  • 3