Synthesis of 5-benzyl and 5-benzyloxybenzyl 2,2'-anhydroudridines and related nucleoside analogs as inhibitors of uridine phosphorylase

Academic Article

Abstract

  • Furanosyl analogs of BAU (5-benzylacyclouridine) and BBAU (5-benzyloxybenzylacyclouridine), two potent inhibitors of uridine phosphorylase, were synthesized and evaluated as potential cancer chemotherapeutic agents. The analogs included ribosides, 2,2'-anhydro nucleosides, arabinosides and deoxyribosides. The anhydrouridine intermediates were potent inhibitors of uridine phosphorylase and good potentiators of FdUrd activity in hunan tumor cells in culture. © 1988, Taylor & Francis Group, LLC. All rights reserved.
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    Author List

  • Chu SH; Weng ZY; Chen ZH; Rowe EC; Chu E; Naguib FNM; el Kouni MH; Cha S; Chu MY
  • Start Page

  • 91
  • End Page

  • 102
  • Volume

  • 7
  • Issue

  • 1