The preparation of 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides by the condensation/cyclization of trilithiated acetoacetanilides with lithiated methyl salicylates

Academic Article


  • Several acetoacetanilides were trilithiated in excess lithium diisopropylamide, and the resulting polylithiated intermediates were regioselectively condensed with lithiated methyl salicylates followed by acid cyclization to substituted 4-oxo-N-aryl-4H-1-benzopyran-2-acetamides (benzopyranone-2-acetamides).
  • Digital Object Identifier (doi)

    Author List

  • Hurst DR; French KL; Angel AJ; Williams AR; Rampey ME; Guion TS; Chan KW; Kassis CM; Studer Martinez SL; Beam CF
  • Start Page

  • 1357
  • End Page

  • 1359
  • Volume

  • 35
  • Issue

  • 6