Soft tissue sarcoma, version 2.2016: Clinical practice guidelines in oncology

Academic Article


  • Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for Soft Tissue Sarcoma (available at provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumor, desmoid tumors, and rhabdomyosarcoma. This manuscript discusses guiding principles for the diagnosis and staging of STS and evidence for treatment modalities that include surgery, radiation, chemoradiation, chemotherapy, and targeted therapy.
  • Digital Object Identifier (doi)

    Author List

  • Von Mehren M; Randall RL; Benjamin RS; Boles S; Bui MM; Conrad EU; Ganjoo KN; George S; Gonzalez RJ; Heslin MJ
  • Start Page

  • 758
  • End Page

  • 786
  • Volume

  • 14
  • Issue

  • 6