Methicillin-resistant Staphylococcus aureus infection in liver transplantation: A matched controlled study

Academic Article

Abstract

  • The purpose of this study was to evaluate the clinical impact of methicillin-resistant Staphylococcus aureus (MRSA) infections on transplant recipients. Methods. Liver and kidney recipients with MRSA infections were retrospectively identified and compared to an age, gender, UNOS status, organ transplanted, and transplant date matched (2:1) non-MRSA-infected recipient control group. All MRSA infections were initially treated with vancomycin, and four (33%) liver recipients were converted to linezolid therapy after failing to improve with vancomycin. Results. The overall MRSA infection incidence was 1.4% (24/1770) with MRSA more common in liver (3.75%; 12/320) than kidney transplants (0.8%; 12/1450) (P <. 001). The most common sites of MRSA infection were blood (42%), lung (38%), and abdomen (29%). The MRSA group had a greater percentage of prior antibiotic usage (79% vs 40%; P <. 0015). The MRSA group experienced more posttransplant complications (52% vs 19%; P <. 011)), and exhibited a trend toward greater length of stay in the intensive care unit (7.8 vs 4.6 days; P =. 09), but not overall length of stay. Survival was similar in MRSA and non-MRSA groups (75% vs 88%; P =. 17). No significant differences in mortality were noted between liver and kidney recipients infected with MRSA (P =. 6). Conclusion. MRSA infection is associated with a higher incidence of posttransplant complications and antibiotic usage in both liver and kidney recipients compared to patients with MRSA infection. © 2005 by Elsevier Inc. All rights reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Schneider CR; Buell JF; Gearhart M; Thomas M; Hanaway MJ; Rudich SM; Woodle ES
  • Start Page

  • 1243
  • End Page

  • 1244
  • Volume

  • 37
  • Issue

  • 2