Pilot study of early corticosteroid elimination after pancreas transplantation

Academic Article

Abstract

  • Early corticosteroid withdrawal has recently been shown to be possible in recipients of simultaneous pancreas kidney transplants; however, its feasibility in solitary pancreas recipients has not been documented. In the present study, we provide evidence that early withdrawal can be achieved in pancreas as well as pancreas-kidney recipients. Methods. Twenty type I diabetics underwent 13 pancreas-kidney transplants and 7 pancreas-only transplants with early withdrawal (methylprednisone 6-day taper). Additional immunosuppression consisted of tacrolimus, mycophenolate mofetil, and thymoglobulin induction (five doses). Results. Transplants included 13 pancreas-kidney, 6 pancreas after kidney transplant, and 1 pancreas after islet transplant. Overall mean follow-up was 7.3 months. One episode of pancreas transplant rejection after pancreas-only transplant was detected on protocol biopsy without biochemical abnormalities. One renal allograft rejection occurred 65 days posttransplant in a pancreas-kidney recipient and was graded as a Banff IA rejection. A single pancreas graft loss occurred due to thrombosis 6 days after pancreas-kidney transplantation. Conclusions. These results indicate that relatively short thymoglobulin induction (five doses) with tacrolimus and mycophenolate mofetil can allow early withdrawal in both pancreas-kidney and pancreas-only transplant recipients. © 2005 by Elsevier Inc. All rights reserved.
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Hanaway MJ; Roy-Chaudhury P; Buell JF; Thomas M; Munda R; Alloway RR; Ellison V; Rudich SM; Fisher L; Woodle ES
  • Start Page

  • 1287
  • End Page

  • 1288
  • Volume

  • 37
  • Issue

  • 2