Reversal of direct thrombin inhibition after cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia

Academic Article


  • We treated persistent hemorrhage after cardiopulmonary bypass in a heart transplant recipient who had received anticoagulation with the direct thrombin inhibitor bivalirudin by a combination therapy aimed at reducing the plasma concentration of the thrombin antagonist (hemodialysis and modified ultrafiltration), increasing the concentration of thrombin at bleeding sites (recombinant factor VIIa), and increasing the plasma concentration of other coagulation factors (fresh frozen plasma and cryoprecipitate). The bleeding was controlled, and there was no thrombotic complication.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 15248203
  • Author List

  • Stratmann G; DeSilva AM; Tseng EE; Hambleton J; Balea M; Romo AJ; Mann MJ; Achorn NL; Moskalik WF; Hoopes CW
  • Start Page

  • 1635
  • End Page

  • 1639
  • Volume

  • 98
  • Issue

  • 6