Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy

Academic Article


  • Cognitive difficulties appear to be a more prevalent clinical feature in progressive supranuclear palsy (PSP) than previously thought, and significant cognitive impairment is prevalent in a majority of patients PSP patients not considered clinically demented. The neurocognitive performance of 200 patients with PSP across multiple sites was examined with a variety of commonly used neuropsychological tests. Results indicate primary executive dysfunction (e.g., 74% impaired on the Frontal Assessment Battery, 55% impaired on Initiation/Perseveration subscale of the Dementia Rating Scale), with milder difficulties in memory, construction, and naming. These results have important clinical implications for providers following patients with PSP. © 2013 The Author.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Gerstenecker A; Mast B; Duff K; Ferman TJ; Litvan I
  • Start Page

  • 104
  • End Page

  • 113
  • Volume

  • 28
  • Issue

  • 2