Chemokine-dependent signaling pathways in the peripheral nervous system

Academic Article


  • Chemokines and their G-protein-coupled receptors play important roles in development, homeostasis, and the innate and adaptive immune response. Pathologic chemokine signaling pathways in the peripheral nervous system can be studied in peripheral nerves using human in vitro models of the blood-nerve barrier (BNB) and a reliable model of acute peripheral nerve in fl ammation called severe murine experimental autoimmune neuritis (EAN). This chapter describes a fl ow-dependent human leukocyte-BNB traf fi cking assay and the reliable induction of EAN in female SJL/J mice as tools to study pro-in fl ammatory chemokinedependent signaling in peripheral nerves. © Springer Science+Business Media New York 2013.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Ubogu EE
  • Start Page

  • 17
  • End Page

  • 30
  • Volume

  • 1013