Liddle syndrome: Clinical and cellular abnormalities

Academic Article


  • Clinical findings resemble those of primary hyperaldosteronism, except that aldosterone secretion is negligible. The fault appears to lie with continuously avid sodium channels in the distal nephron, resulting in excessive salt absorption, potassium wasting, and severe hypertension. Insights gained in this disorder may help clarify more common forms of low- renin hypertension.
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    Author List

  • Warnock DG; Bubien JK
  • Volume

  • 29
  • Issue

  • 7