Idiopathic Anorectal Ulceration in Patients with Human Immunodeficiency Virus Infection

Academic Article


  • Opportunistic infections and neoplasms of the anorectum have heen reported in patients with human immunodeficiency virus (HIV) infection. More recently, idiopathic alcerative lesions of the colon and rectum have been described. At our center over a 3‐yr period, four patients were identified with ulcerative lesions of the rectum and/or anus that remained idiopathic despite an extensive clinical, serologic, and histopathologic evaluation. Three patients had the acquired immunodeficiency syndrome, and in one anorectal disease was the index manifestation of HIV infection. Only one of the patients had recently engaged in receptive anal intercourse. The presenting complaints were gastrointestinal hieeding in two, which was severe in one, and/or anorectal pain. Multiple colonoscopic evaluations with hiopsy of the distal colorectum documented a solitary ulcer of the rectum in one, solitary ulcer involving the anorectum in two, and multiple ulcers of the rectum and anorectnm in one. In three patients, colonoscopy to the cecum demonstrated no additional lesions. In patients with HIV infection, ulcerative lesions of the anorectum may remain unexplained despite an exhaustive evaluation. The etiology of these lesions, as well as appropriate therapy, remains to be determined. Copyright © 1994, Wiley Blackwell. All rights reserved
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Wilcox CM; Schwartz DA
  • Start Page

  • 599
  • End Page

  • 604
  • Volume

  • 89
  • Issue

  • 4