Differential inotropic actions of ethmozine and ethacizin (diethylamine analog of ethmozine)

Academic Article

Abstract

  • The direct inotropic actions of ethmozine and of its diethylamine analog, ethacizin, were studied in the presence of muscarinic and beta-adrenoreceptor blockade in 12 ferret right ventricular papillary muscles. In each muscle ethmozine caused a small but consistent and significant (p < 0.05) increase in contractile performance, whereas ethacizin significantly (p < 0.05) diminished contractillity. Although both phenothiazines are fast channel blockers, it appears that the net positive inotropic action of ethmozine is due to its stimulatory effect on the slow inward current and that the negative inotropic action of ethacizin is largely due to its recently demonstrated decreases of the slow inward current. © 1986.
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    Digital Object Identifier (doi)

    Author List

  • Urthaler F; Rosenshtraukh LV; Walker AA; Hageman GR
  • Start Page

  • 462
  • End Page

  • 465
  • Volume

  • 111
  • Issue

  • 3