The authors evaluated 196 consecutive survivors of acute myocardial infarction and performed selective coronary angiography in 117 of 131 (89%) patients who were deemed candidates for angiography by clinical criteria. Overall, left main CAD (≥70% stenosis) was found in 10 patients (8.5%), 3 vessel CAD in 41 patients (35%), 2 vessel CAD in 37 patients (31.5%), single vessel disease in 27 patients (23%) and zero vessel disease in 2 patients (2%). Factors suggesting multivessel disease included older age, history of prior myocardial infarction, and post-infarction convalescence complicated by angina pectoris. Factors not discriminating between single and multivessel disease were sex, infarct extent (transmural vs non-transmural), (3) infarct location (anterior vs inferior), and post-infarction convalescence complicated by late arrhythmia or heart failure. This study demonstrates that multivessel coronary artery disease is common in survivors of myocardial infarction and is suggested by the occurrence of post-infarction angina and by the history of an antecedent myocardial infarction. Coronary angiography can be performed safely within 30 days after myocardial infarction in patients with an uncomplicated convalescence and with mild risk in those with a complicated convalescence.